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US 7,678,916 B2Granted
Process
AssigneeCipla Limited
InventorsRajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Manjinder Singh Phull, Dilip Ramda Birari
Life of this patent
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Abstract
The present invention relates to processes for the preparation of rosiglitazone, rosiglitazone prepared thereby and pharmaceutical compositions and therapeutic uses thereof, and methods of treatment employing the same.
Claims8
A process of preparing crystalline rosiglitazone maleate Form A, having an X-ray diffraction pattern with characteristic peaks (2θ):
- 9.5, 15.86, 15.02, 17.00, 18.52, 21.99, 23.58, 25.06 and 26.55, which process comprises preparing a mixture which comprises rosiglitazone free base, and maleic acid, present in a water miscible solvent, stirring said mixture and heating to obtain a solution, filtering the solution to obtain a clear filtrate and adding a water immiscible solvent thereto, followed by stirring and cooling so as to isolate crystalline rosiglitazone maleate Form A.
Dependencies are inferred from the claim text.