1,6 naphthyridines useful as inhibitors of SYK kinase

A method for modulating the effects of allergic or inflammatory disease in a warm-blooded animal comprising administering to the animal a therapeutically effective amount of a SYK kinase inhibitor of formula (I)

• wherein:
• R3 is H, C1-3alkyl, halogen or phenyl;
• R5 is N(R9)(R10) or OR11 wherein
• R9 is H or C1-3alkyl,
• R10 is aminoC2-6alkyl, C1-4alkyaminoC2-6alkyl, diC1-4alkylaminoC2-6alkyl, C1-4alkoxyC2-6alkyl or hydroxyC2-6alkyl, wherein one methylene group in said C2-6alky is optionally replaced with an oxygen, sulfur, NH, or NCH3 and wherein each methylene group in said C2-6alkyl is optionally substituted with a halogen, cyano or hydroxy group, or R10 is C3-7cycloalkyl, heterocycloalkyl, heteroaryl, C3-7cycloalkylC1-4alkyl, heterocycloalkylC1-4alkyl, arylC1-4alkyl or heteroarylC1-4alkyl each optionally substituted with one or more C1-4alkyl, amino, C1-4alkylamino, diC1-4alkylamino, aminoC1-3alkyl, C1-4alkylaminoC1-3alkyl, diC1-4alkylaminoC1-3alkyl, halogen, hydroxy, aminocarboxy or benzyl groups, or R9 and R10 together with the nitrogen they are bonded to may form a heterocycloalkyl group containing one or more heteroatoms which is optionally substituted with one or more C1-4alkyl, amino, C1-4alkylamino, diC1-4alkylamino, aminoC1-3alkyl, C1-4alkylaminoC1-3alkyl, diC1-4alkylaminoC1-3alkyl, halogen, hydroxy, aminocarboxy or benzyl groups, and
• R11 is aminoC2-6alkyl, C1-4alkylaminoC2-6alkyl, diC1-4alkylaminoC2-6alkyl, C1-4alkoxyC2-6alkyl or hydroxyC2-6alkyl, wherein one methylene group in said C2-6alkyl is optionally replaced with an oxygen, sulfur, NH, or NCH3 and wherein each methylene group in said C2-6alkyl is optionally substituted with a halogen, cyano or hydroxy group, or R11 is C3-7cycloalkyl, heterocycloalkyl, heteroaryl, C3-7cycloalkylC1-4alkyl, heterocycloalkylC1-4alkyl, arylC1-4alkyl or heteroarylC1-4alkyl each optionally substituted with one or more C1-4alkyl, amino, C1-4alkylamino, diC1-4alkylamino, aminoC1-3alkyl, C1-4alkylaminoC1-3alkyl, diC1-4alkylaminoC1-3alkyl, halogen, hydroxy, aminocarboxy or benzyl groups;
• R7 is phenyl, naphthyl, furyl, thienyl, pyridyl, indolyl, benzothiazolyl or pyrrolyl optionally substituted with one or more C1-3alkoxy, halogen, CF3, CF3O, hydroxy, C1-3akyl, amino, C1-3alkylamino, diC1-3alkylamino, C1-3alkylaminoC1-3alkyl, diC1-3alkylaminoC1-3alkyl, (C1-3alkylaminoC1-3alkyl)(C0-3alkyl)amino, (diC1-3alkylaminoC1-3alkyl)(C0-3alkyl)amino, C1-3alkylthio, aminocarboxy, C1-3alkylcarbonyl, ureido optionally substituted with C1-3alkyl, C(O)OC1-4alkyl, C(O)OH, acetamido or heterocycloaklyl groups, or with a phenyl group which is optionally substituted with one or more C1-3alkoxy, halogen, CF3, CF3O, hydroxy, C1-3alkyl, amino, C1-3alkylamino, diC1-3alkylamino, C1-3alkylaminoC1-3alkyl, diC1-3alkylaminoC1-3alkyl, C1-3alkylthio, aminocarboxy, C1-3alkylcarbonyl, ureido optionally substituted with C1-3alkyl, C(O)OC1-4alkyl, C(O)OH, acetamido, heteroaryl or heterocycloalkyl groups;
• and
• R8 is H;
• with the proviso that R3 is not hydrogen and R8 is not hydrogen when R7 is methoxy-substituted phenyl and R5 is
• or a pharmaceutically acceptable salt thereof.