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US 7,678,909 B1Granted
Dipeptidyl peptidase inhibitors
AssigneeTakeda Pharmaceutical Company Limited
InventorsLaurence E. Burgess, Scott D. Cowen, Stephen L. Gwaltney, II, Jeongboeb Seo, Jeffrey A. Stafford
Life of this patent
Estimating the term…
Abstract
Compounds are provided which may be used to inhibit DPP-IV comprising the formula: wherein the substituents are as described in the specification and claims.
Claims19
A compound comprising the formula:
- wherein
- Q is selected from the group consisting of CO and C═NR5;
- Z is nitrogen;
- R1 is cyclohexyl unsubstituted or substituted with one or more substituents selected from the group consisting of halo, amino, aminoalkyl, cyano, (C1-3)alkyl and hydroxy;
- R2 is hydrogen or (C1-6)alkyl unsubstituted or substituted with one or more substituents selected from the group consisting of halo, amino, cyano, (C1-3)alkyl and aryl;
- R3 and R4 are each independently selected from the group consisting of hydrogen, halo, amino and (C1-10)alkyl;
- R5 is hydrogen or (C1-10)alkyl;
- L is a linker comprising between 1, 2 or 3 atoms of carbon;
- and
- X is aryl, unsubstituted or substituted with one or more substituents selected from the group consisting of halo, cyano, amino and (C1-3)alkyl.
7 more elements
A compound selected from the group consisting of:
- 2-[2-(3-Amino-cyclohexyl)-5-benzyl-4-oxo-4,5-dihydro-imidazo[4,5-c]pyridin-3-ylmethyl]-benzonitrile;
- and
- 2-[2-(3-Amino-cyclohexyl)-5-ethyl-4-oxo-4,5-dihydro-imidazo[4,5-c]pyridin-3-ylmethyl]-benzonitrile.
A compound selected from the group consisting of:
- 2-[2-(3-(R)-Amino-cyclohexyl)-5-benzyl-4-oxo-4,5-dihydro-imidazo[4,5-c]pyridin-3-ylmethyl]-benzonitrile;
- and
- 2-[2-(3-(R)-Amino-cyclohexyl)-5-ethyl-4-oxo-4,5-dihydro-imidazo[4,5-c]pyridin-3-ylmethyl]-benzonitrile.
Dependencies are inferred from the claim text.