Antisense modulation of superoxide dismutase 1, soluble expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsC. Frank Bennett, Susan M. Freier, Thomas P. Condon
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding superoxide dismutase 1, soluble. Methods of using these compounds for modulation of superoxide dismutase 1, soluble expression and for treatment of diseases associated with expression of superoxide dismutase 1, soluble are provided.
Claims34
A compound 20 to 50 nucleobases in length comprising the nucleobase sequence of SEQ ID NO:
- 98.
A compound consisting of the nucleobase sequence of SEQ ID NO:
- 98.
A compound comprising a modified oligonucleotide consisting of 12 to 30 linked nucleosides and having a nucleobase sequence comprising at least 12 contiguous nucleobases of the nucleobase sequence set forth in SEQ ID NO:
- 98.
Dependencies are inferred from the claim text.