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US 7,678,894 B2Granted
Nucleotide analogs
AssigneeHelicos BioSciences Corporation
InventorSuhaib Siddiqi
Life of this patent
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Abstract
The disclosure provides nucleotide analogs and methods of their use. Analogs of the invention comprise a reporter molecule (label) attached via the N4, N6, O4, or O6 position of the nitrogenous base portion of the analog. In a preferred embodiment, nucleotide analogs of the invention comprise a label attached to the nitrogenous base portion of the analog via a cleavable linker at the N4, O4, N6 or O6 position.
Claims14
A nucleotide analog, comprising:
- A nitrogenous base;
- A linker attached at the N4, N6, O4, or O6 of said nitrogeneous base;
- and
- A detectable label attached to said nitrogenous base via said linker,
- wherein said linker comprises a cleavable bond such that a native nucleotide monophosphate is regenerated upon incorporation of said analog into a nucleic acid duplex.
2 more elements
Dependencies are inferred from the claim text.