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US 7,678,886 B2Granted
Pharmaceutical compositions of adiponectin variants and methods of storage
AssigneeXencor, Inc.
InventorsJonathan Zalevsky, Duc-Hanh Thi Nguyen, Gregory L. Moore, Sergei A. Ezhevsky, John R. Desjarlais, Arthur J. Chirino, Darian Cash, Matthew J. Bernett
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Abstract
A composition comprising an adiponectin variant at a concentration of at least 2.0 mg/mL, and a pharmaceutically acceptable carrier, wherein less than 20% of said adiponectin variant would aggregate after storage at 4° C. for one week in 10 mM PO4, 150 mM NaCl buffer.
Claims8
A composition comprising an adiponectin variant comprising amino acids 110-244 of human adiponectin as set forth in SEQ ID NO:
- 1 with the exception of mutations Y122S and I125E, at a concentration of at least 2.0 mg/mL, and a pharmaceutically acceptable carrier, wherein less than 20% of said adiponectin variant becomes insoluble after storage at 4° C. for one week in 10 mM PO4, 150 mM NaCl buffer.
Dependencies are inferred from the claim text.