Processable molecularly imprinted polymers
AssigneeThe Johns Hopkins University
InventorsGlen E. Southard, George M. Murray
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Abstract
A process is provided herein for preparing molecularly imprinted polymers for detecting a target analyte by Reversible Addition Fragmentation Chain Transfer (RAFT). The process includes providing a complex having the formula L3M wherein L is a β-diketone ligand containing a chain transfer moiety and L3 can be the same or different ligands, and M is a lanthanide element; reacting the complex with the target analyte to provide an adduct containing the target analyte; co-polymerizing the adduct with a monomer and cross-linking agent to provide a polymer; and removing the target analyte from the polymer to provide the molecularly imprinted polymer.
Claims45
A process for preparing a molecularly imprinted polymer for detecting a target analyte comprising the steps of:
- (a) providing a complex comprising a compound of the general formula L3M wherein L is the same or different and is a β-diketone ligand containing the same or different chain transfer moiety and M is a lanthanide element;
- (b) reacting the complex with a target analyte to provide an adduct containing the target analyte;
- (c) co-polymerizing the adduct with a monomer and cross-linking agent to provide a polymer;
- and,
- (d) removing the target analyte from the polymer to provide the molecularly imprinted polymer.
A polymer comprising the reaction product of(a) a complex comprising a compound of the general formula L3M wherein L is the same or different and is a β-diketone ligand containing the same or different chain transfer moiety and M is a lanthanide element, the complex being capable of binding an analyte to be detected;
- (b) a monomer;
- and (c) optional crosslinking agent, wherein said polymer undergoes a detectable luminescence change upon exposure to the analyte to be detected.
A molecularly imprinted polymer obtained by the steps of (a) providing a reaction product of(i) a complex comprising a compound of the general formula L3M wherein L is the same or different and is a β-diketone ligand containing the same or different chain transfer moiety and M is a lanthanide element and (ii) a target analyte;
- (b) copolymerizing the reaction product of step (a) with monomer and optional crosslinking agent to form a polymer;
- and (c) removing the target analyte from the polymer to provide a molecularly imprinted polymer which selectively binds to the target analyte and undergoes a detectable luminescence change when the target analyte binds thereto.
Dependencies are inferred from the claim text.