Bis(thio-hydrazide amide) formulation
AssigneeSynta Pharmaceuticals Corp.
InventorsWalter J. Lunsmann, Ninad Deshpanday
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Abstract
Disclosed herein are compositions comprising a compound represented by structural formula (I): 2 g of which is reconstitutable in 10 mL of a water in less than 10 minutes, and methods for preparing these compositions. Also disclosed are compositions comprising a compound represented by structural formula (I) and a pharmaceutically acceptable excipient, wherein the molar ratio of said compound to said excipient is from 1:20 to 1:1, and methods for preparing these compositions.
Claims16
A composition comprising a compound represented by the following structural formula:
- wherein:
- M+ is a pharmaceutically acceptable monovalent cation and M2+ is a pharmaceutically acceptable divalent cation;
- and
- the composition further comprises a pharmaceutically acceptable crystalline bulking excipient in a molar ratio of the compound to the excipient from 1:20 to 1:1, and wherein the composition is a lyophilizate.
A composition comprising a compound represented by the following structural formula:
- wherein:
- M+ is a pharmaceutically acceptable monovalent cation and M2+ is a pharmaceutically acceptable divalent cation;
- and
- the composition further comprises a pharmaceutically acceptable crystalline bulking excipient in a molar ratio of the compound to the excipient from 1:20 to 1:1, and wherein the composition is a lyophilized and annealed composition.
Dependencies are inferred from the claim text.