Organic compounds for the treatment of inflammatory or allergic conditions

A compound of formula (I)

• in free or pharmaceutically acceptable salt form,
• wherein
• R1 is selected from R1aS—, R1aO— and R1aNR9—, wherein R1a is
• wherein
• R1b and R1c are independently selected from H, C1-C8-alkyl, and together with the carbon atom to which they are attached form a divalent C3-C8-cycloaliphatic group;
• R2 and R3 are independently selected from H, C1-C8-alkyl, and together with the carbon atom to which they are attached form a divalent C3-C8-cycloaliphatic group;
• R4 and R5 are independently selected from H, halogen, C1-C8-alkyl, C1-C8-haloalkyl, a C3-C15-carbocyclic group, nitro, cyano, SO2R5a, C1-C8-alkylcarbonyl, C1-C8-alkoxycarbonyl, C1-C8-alkoxy, C1-C8-haloalkoxy, —SR5b, carboxy, carboxy-C1-C8-alkyl, amino, amino(C1-C8-alkyl), C1-C8-alkylamino(C1-C8-alkyl), di(C1-C8-alkyl)amino(C1-C8-alkyl), C1-C8-alkylamino, di(C1-C8-alkyl)amino, SO2NR5cR5d, C(O)NR5eR5f, C1-C8-hydroxyalkyl, NR5gSO2R5h, NR5i(CO)R5j, SOR5k, a C6-C15 aromatic carbocyclic group and a 4- to 10-membered heterocyclic group having one or more heteroatoms selected from the group consisting of oxygen, nitrogen and sulphur;
• R5a, R5k and R5b are independently selected from C1-C8-alkyl, C1-C8-hydroxyalkyl, C1-C8 alkylamino(C1-C8-alkyl), di(C1-C8-alkyl)amino(C1-C8-alkyl), C1-C8-cyanoalkyl, a C3-C15-carbocyclic group, C1-C8-haloalkyl and a 4- to 10-membered heterocyclic group having one or more heteroatoms selected from the group consisting of oxygen, nitrogen and sulphur;
• R5c, R5d, R5e and R5f are, independently, H, C1-C8-alkyl, C1-C8-hydroxyalkyl, C1-C8-alkylamino(C1-C8-alkyl), di(C1-C8-alkyl)amino(C1-C8-alkyl), C1-C8-cyanoalkyl, a C3-C15-carbocyclic group, C1-C8-haloalkyl, a 4- to 10-membered heterocyclic group having one or more heteroatoms selected from the group consisting of oxygen, nitrogen and sulphur, or, together with the nitrogen atom to which they are attached, form a C4-C10-heterocyclic group;
• R5g and R5i are independently selected from H, C1-C8-alkyl, C1-C8-hydroxyalkyl, C1-C8-alkylamino(C1-C8-alkyl), di(C1-C8-alkyl)amino(C1-C8-alkyl), C1-C8-cyanoalkyl, a C3-C15-carbocyclic group, C1-C8-haloalkyl and a 4- to 10-membered heterocyclic group having one or more heteroatoms selected from the group consisting of oxygen, nitrogen and sulphur;
• R5h and R5j are independently selected from C1-C8-alkyl, a C3-C15-carbocyclic group, a 4- to 10-membered heterocyclic group having one or more heteroatoms selected from the group consisting of oxygen, nitrogen and sulphur, C1-C8-hydroxyalkyl, amino(C1-C8-alkyl), C1-C8-alkylamino(C1-C8-alkyl), di(C1-C8-alkyl)amino(C1-C8-alkyl) and C1-C8-cyanoalkyl;
• R6 and R7, together with the nitrogen to which they are attached form, a 4- to 10-membered heterocyclic group containing the indicated nitrogen atom as a ring heteroatom and optionally at least one ring heteroatom selected from the group consisting of nitrogen, oxygen and sulphur, which ring is unsubstituted or substituted by C1-C4-alkyl, cyano-C1-C4-alkyl, C1-C8-alkylamino or di(C1-C8-alkylamino);
• R8 is selected from H, C1-C8-alkyl, C3-C15-cycloalkyl, C1-C8-alkyl(C6-C15-aromatic carbocyclic group) and C6-C15-aromatic carbocyclic group;
• R9 is selected from H, C1-C8-alkyl, C3-C15-cycloalkyl, C1-C8-alkyl(C6-C15-aromatic carbocyclic group), and C6-C15-aromatic carbocyclic group;
• X is —CH2—, —CH(C1-C8-alkyl)-, —CO—, —CH(OC1-C8-alkyl)-, —C(halogen)2-, —O—, —S—, —SO— or, —SO2—;
• Y is —O—, —S—, —CH2— or —NR7(C1-C8-alkyl)-;
• m and n are each, independently, an integer selected from 0-3;
• v is an integer selected from 1-3;
• and
• w is an integer selected from 0-3.