Pharmaceutically active isoindoline derivates
AssigneeCelgene Corporation
InventorsHon-Wah Man, George W Muller
Life of this patent
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Abstract
Isoindolin-1-one and Isoindoline-1,3-dione substituted in the 2-position with an α-(3,4-disubstituted phenyl)alkyl group and in the 4- and/or 5-position with a nitrogen-containing group are inhibitors of, and thus useful in the treatment of disease states mediated by, TNFα and phosphodiesterase. A typical embodiment is 2-[1-(3-ethoxy-4-methoxyphenyl)2-methylsulfonylethyl]4,5-diaminoisoindoline-1,3-dione.
Claims11
A method of treating Crohn's disease, inflammatory bowel disease, psoriasis, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, or ulcerative colitis which comprises administering thereto an effective amount of a compound of the formula:
- or an acid addition salt thereof.
Dependencies are inferred from the claim text.