Anthranilamide and 2-amino-heteroarene-carboxamide compounds

A compound of formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• R1, R2, R4 and R5 are independently hydrogen, C1-C6alkyl, C1-C6alkoxy or halogen;
• R3 is selected from the group consisting of:
• (1) C3-C6alkyl,
• (2) halogen-C1-C6alkyl,
• (3) C3-C6cycloalkyl optionally substituted by halogen or alkoxy,
• (4) Si(C1-C6alkyl)3,
• (5) —OR12, wherein R12 is (a) C1-C6alkyl optionally substituted by halogen, hydroxy, COOC1-C6alkyl, C3-C6cycloalkyl or phenyl which phenyl is optionally substituted by halogen or cyano, (b) halogen-C1-C6alkyl, (c) C3-C6cycloalkyl, (d) phenyl, (e) benzyl optionally substituted by halogen or cyano, or (f) S(O)2-C1-C6alkyl, and
• (6) pentafluorosulfuranyl;
• or
• R2 and R3 taken together with the carbon atoms they are attached to form a 5- or 6-membered carbocyclic ring or a 5- or 6-membered heterocyclic ring containing one or two heteroatoms selected from N, O or S;
• R6 is hydrogen or C1-C6alkyl;
• R7 and R8 are independently hydrogen, C1-C6alkyl, hydroxy or halogen;
• R9 is selected from the group consisting of:
• (1) hydrogen,
• (2) C1-C6alkyl,
• (3) C2-C6alkenyl,
• (4) halogen-C1-C6alkyl,
• (5) heterocyclyl,
• (6) heteroaryl,
• (7) phenyl,
• (8) naphthyl, and
• (9) —NR14R15, wherein R14 and R15 independently are hydrogen, C1-C6alkyl or phenyl optionally substituted by halogen;
• wherein said heteroaryl or phenyl is optionally substituted by:
• (a) halogen, (b) C1-C6alkyl optionally substituted by halogen, (c) C1-C6alkoxy optionally substituted by halogen or (d) phenyl
• R10 and R11 are independently selected from the group consisting of:
• (1) hydrogen, (2) halogen, (3) C1-C6alkyl optionally substituted by hydroxy, (4) —COR wherein R is C1-C6alkyl optionally substituted by halogen, C1-C6alkoxy, or C3-C6cycloalkyl, (5) —CH2—COO—CH2CH3, —CH2—COOH, or —CH2—CH2—COOH, (6) S(O)2—C1-C6alkyl, (7) C3-C6cycloalkyl, (8) cyano, and (9) phenyl;
• or together R10 and R11 are C1-C6alkylene;
• A is CR17 or N, wherein R17 is hydrogen, halogen, C1-C6alkyl, C1-C6alkoxy or C2-C6alkenyl;
• B is CR18 or N, wherein R18 is hydrogen, halogen, C1-C6alkyl, C1-C6alkoxy or C2-C6alkenyl;
• D is CR19 or N, wherein R19 is hydrogen, halogen, C1-C6alkyl, C1-C6alkoxy, C2-C6alkenyl or phenyl;
• and
• E is CR20 or N, wherein R20 is hydrogen, halogen, C1-C6alkyl, C1-C6alkoxy or C2-C6alkenyl;
• or alternatively,
• E is CR20 and -A-B-D- is —N—O—, —NR21—N—, —S—N—, —S—CH— or —CH—S—, wherein R21 is hydrogen, halogen, C1-C6alkyl, C1-C6alkoxy or C2-C6alkenyl;
• or
• E is N and -A-B-D- is —N—O—, —S—N—, —S—CH—, —CH—CH— or —CH—S—;
• or
• E is S and -A-B-D- is —CH—CH—;
• and
• n is 1, 2 or 3.