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US 7,678,813 B2Granted
Azadecalin Glucocorticoid receptor modulators
AssigneeCorcept Therapeutics, Inc.
InventorsRobin D. Clark, Nicholas C. Ray, Paul Blaney, Christopher Hurley, Hazel Hunt, David Clark, Karen Williams
Life of this patent
Estimating the term…
Abstract
The present invention provides a novel class of azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
Claims21
A compound having the formula:
- wherein:
- L4 is selected from a bond, substituted or unsubstituted alkylene, and substituted or unsubstituted heteroalkylene;
- L3 is unsubstituted methylene;
- the dashed line b is optionally a bond;
- R3 has the formula:
- wherein
- q is an integer selected from 1 to 5;
- R3D is a member independently selected from hydrogen, halogen, —OH, —COOH, —CF3, —NH2, —SH, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —NR3D1R3D2, —OR3D3, —C(O)NR3D4R3D5, and —C(O)R3D6, wherein
- R3D1, R3D2, R3D3, R3D4, R3D5, and R3D6 are members independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, wherein
- R3D1 and R3D2 are optionally joined to form a substituted or unsubstituted ring with the nitrogen to which they are attached, and
- R3D4 and R3D5 are optionally joined to form a substituted or unsubstituted ring with the nitrogen to which they are attached;
- R4 has the formula:
- wherein
- R4G is a member independently selected from hydrogen, halogen, —OH, —COOH, —CF3, —NH2, —SH, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl;
- A is a substituted or unsubstituted ring selected from substituted or unsubstituted (C3-C7)cycloalkyl, substituted or unsubstituted 3-7 membered heterocycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl;
- X is a member selected from a bond, —S(O)v—, and —S(O)vNR4I—, wherein
- R4I is a member selected from hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted heteroalkyl, and
- v is 0, 1, or 2;
- and
- w is an integer from 1 to 5.
17 more elements
A compound selected from the group consisting of:
Dependencies are inferred from the claim text.