Isoquinoline and benzo[H] isoquinoline derivatives, preparation and therapeutic use thereof as antagonists of the histamine H3 receptor

A compound of formula (I):

• wherein:
• represents a 6-membered unsaturated carbocycle with double bonds which is optionally substituted by one or two substituents chosen, independently of one another, from a halogen atom, a hydroxyl, a nitro, cyano, C1-2 perhaloalkyl or C1-3 alkyl group or a phenyl;
• 1 is 0 to 2;
• m is 0 to 2;
• wherein the aminocycle comprising —(C)l—, —(C)m— and —NR1- forms a pyrrolidine;
• n is 0 to 6;
• —(C)l—, —(C)m— and —(C)n— represent, independently of one another, a —Cx-z— alkylene group, optionally substituted by 1 to 4 substituents chosen from a halogen atom, a hydroxyl, nitro, cyano, amino, C1-2 perhaloalkyl or C1-3 alkyl group or a phenyl;
• and when l, m and n are 0, —(C)0— represents a bond;
• R1 represents
• a hydrogen atom,
• a C1-3 alkyl group,
• a C1-6 alkylcarbonyl,
• a C1-6 alkoxycarbonyl,
• it being possible for each to be substituted by a halogen atom, a hydroxyl, C1-3 alkoxy, nitro, cyano or amino group or aryl;
• a C1-3 alkylaryl group,
• a monocyclic heteroaryl, and
• an aryl;
• the aryl and heteroaryl groups optionally being substituted by 1 to 4 substituents chosen from a halogen atom, a hydroxyl, nitro, cyano, amino, C1-3 monoalkylamino, C2-6 dialkylamino, C1-3 alkyl, C1-2 perhaloalkyl, C1-3 haloalkyl or C1-3 alkoxy group or a alkylidenedioxy group;
• and
• R2 represents
• a C1-6 alkyl group or a C3-6 cycloalkyl group, each optionally being substituted by 1 to 4 substituents chosen from a halogen atom, a hydroxyl, nitro, cyano, amino, C1-3 monoalkylamino, C2-6 dialkylamino, C1-2 perhaloalkyl, C1-3 haloalkyl, C1-3 alkoxy or C3-6 cycloalkyl group, a monocyclic heteroaryl, a bicyclic heteroaryl or an aryl group itself optionally substituted by 1 to 4 substituents chosen from a halogen atom, a hydroxyl, nitro, cyano, amino, C1-3 monoalkylamino, C2-6 dialkylamino, C1-3 alkyl, C1-2 perhaloalkyl, C1-3 haloalkyl or C1-3 alkoxy group or a C1-3 alkylidenedioxy group,
• or a salt thereof.