US 7,678,788 B2 · Diazabicyclic aryl derivatives

Abstract

This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

Claims4

Dependent claims

A diazabicyclic aryl compound represented by Formula I

any of its enantiomers or any mixture of its enantiomers, or a pharmaceutically acceptable addition salt thereof, wherein
n is 2;
X and Y, independently of each other, represents CR2 or N;
R1 represents alkyl, cycloalkyl, cycloalkyl-alkyl, alkoxy, CF3, OCF3, CN, nitro, 2-nitro -phenyl, 3-nitro-phenyl, 4-nitro-phenyl, 3-trifluoromethyl-phenyl, 4-trifluoromethyl-phenyl, 2-halo-5-trifluoromethyl-phenyl, 2-amino-phenyl, 3-amino-phenyl, N-4-formylamino-phenyl, N-2-acetylamino-phenyl, N-3-acetylamino-phenyl, or N-4-acetylamino-phenyl;
and
R2 represents hydrogen, alkyl or halo.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/547,157Filed 4 Feb 2004 · us provisional application

Priority

DK 2003 0031027 Feb 2003

Published

US 2006/0148789 A16 Jul 2006

Granted

16 Mar 2010

Term ends

Not estimatedThe source records don’t support an estimate.

Classification35 codes

C07D 471/08
In which the condensed system contains two hetero rings: bridged systems
A61P 1/00
Drugs for disorders of the alimentary tract or the digestive system
A61P 1/12
Drugs for disorders of the alimentary tract or the digestive system: antidiarrhoeals
A61P 1/14
Drugs for disorders of the alimentary tract or the digestive system: prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics,…

Diazabicyclic aryl derivatives

Life of this patent

Diazabicyclic aryl derivatives

Life of this patent

Abstract

Claims4