Protein formulations for use at elevated temperatures
AssigneeJohnson & Johnson Regenerative Therapeutics, LLC
InventorsVenkata Garigapati, Dongling Su, Julius Lopez
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Abstract
Liquid formulations of bone morphogenetic proteins are provided for prolonged use at elevated temperatures. More specifically, the invention relates to liquid formulations comprising rhGDF-5, trehalose, and one or more biocompatible excipients that provide stability to the protein for at least 30 days at temperatures up to body temperature.
Claims12
A composition comprising GDF-5 and excipients in an acidic solution, wherein the excipients are trehalose, present in the amount of 60% w/v, an amino acid, and a trialkylammonium salt.
A method for stabilizing a GDF-5 solution comprising providing GDF-5 in an acidic solution, adding an amount of trehalose to provide 60% w/v solution of trehalose, and adding an amino acid, and a trialkylammonium salt.
Dependencies are inferred from the claim text.