Diagnosis and treatment of neuroectodermal tumors
AssigneeTransmolecular, Inc.
InventorsHarald W. Sontheimer, Susan A. Lyons
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Abstract
The present invention provides fusion proteins for the detection and treatment of neuroectodermal tumors. Previous work demonstrated that chlorotoxin is specific for glial-derived or meningioma-derived tumor cells. The current invention has extended the use of chlorotoxin-cytotoxin fusion proteins to treat the whole class neuroectodermal tumors such as gliomas, meningiomas, ependymonas, medulloblastomas, neuroblastomas, gangliomas, pheochromocytomas, melanomas, PPNET's, small cell carcinoma of the lung, Ewing's sarcoma, and metastatic tumors in the brain. Also, diagnostic methods are provided for screening neoplastic neuroectodermal tumors.
Claims8
A method of delivering a cytotoxic moiety to a neuroectodermal tumor, comprising:
- administering a composition comprising an agent consisting of chlorotoxin fused to a cytotoxic moiety to an individual having a neuroectodermal tumor, such that the agent binds specifically to the tumor.
Dependencies are inferred from the claim text.