Method for enhancing T cell reactivity toward tumour antigens
AssigneeCelldex Therapeutics, Inc.
InventorsJonathan Robert Lamb, Gerard Francis Hoyne
Life of this patent
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Abstract
Provided is a method of vaccinating a patient against a tumor by administering an agent to reduce or prevent interaction between Notch and a Notch ligand, or expression or processing of Notch or a Notch ligand. In one embodiment, this is accomplished by administering to the patient a tumor antigen expressed by the tumor and exposing an antigen presenting cell in the patient to an agent that reduces or prevents interaction, expression or processing of Notch or a Notch ligand in a T cell.
Claims12
A method of treating a tumour by reducing or preventing interaction between Notch and an endogenous Notch ligand in a patient in need thereof, comprising the steps of:
- (a) administering a tumour antigen expressed by the tumour to a patient;
- and
- (b) exposing the patient to an agent, wherein the agent is capable of reducing or preventing interaction between Notch and an endogenous Notch ligand, and wherein the agent is a polypeptide having a DSL domain at the N-terminus and 3 to 8 EGF-like repeats wherein the polypeptide does not activate Notch.
Dependencies are inferred from the claim text.