Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype
AssigneeQueen's University at Kingston
InventorsCharles H. Graham, Lynn-Marie Postovit, Michael A. Adams, Jeremy P. W. Heaton
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods and formulations for inhibiting, treating and preventing a malignant cell phenotype, cell, tumor and/or disease. Administration of nitric oxide mimetics, such as low doses, is sufficient to increase, restore or maintain nitric oxide-mediated signaling in cells so that malignant cell phenotypes, cells, tumors and/or diseases are inhibited or prevented. These methods and formulations are particularly useful in treating and preventing cancer in animals.
Claims24
A method for controlling, treating and/or decreasing progression of cancer, malignancies, and/or tumor angiogenesis in a human subject, said method comprising:
- administering a low dose of a nitric oxide mimetic to said human subject, to control, treat and/or decrease progression of said cancer, malignancies, and/or tumor angiogenesis;
- wherein said nitric oxide mimetic is an organic nitrate;
- wherein said low dose is 3 to 10,000 fold lower than a dose of said nitric oxide mimetic that produces vasodilation in said human subject, and wherein said low dose of said nitric oxide mimetic does not induce substantial tolerance in said human subject
- wherein said low dose of a nitric oxide mimetic enhances the efficacy of, and/or decreases the resistance to an antimalignant therapeutic modality;
- and
- wherein said antimalignant therapeutic modality includes radiation therapy, thermal therapy, immunotherapy, or chemotherapy, or a combination thereof.
Dependencies are inferred from the claim text.