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US 7,678,378 B2Granted
Compounds for intracellular delivery of therapeutic moieties to nerve cells
AssigneeManzanita Pharmaceuticals, Inc.
InventorsRobert R. Webb, Constance A. McKee
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Abstract
A compound for delivering a non-cytotoxic therapeutic moiety into nerve cells, the compound having the general formula: B-L-TM where: B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; TM is a therapeutic moiety which has a non-cytotoxic therapeutic effect when absorbed by a nerve cell; and L is a linker coupling B to TM.
Claims15
A composition comprising:
- a compound having the general formula:
- B-L-TM
- where:
- B is nerve growth factor (NGF) or a fragment thereof which selectively binds to a neurotrophin receptor;
- TM is a noncytotoxic, antiviral moiety other than the nerve growth factor or fragment thereof;
- and
- L is a cleavable linker coupling B to TM;
- and
- a pharmaceutically acceptable vehicle.
6 more elements
Dependencies are inferred from the claim text.