Use of inhibitors for the treatment of RTK-hyperfunction-induced disorders, particularly cancer
AssigneeMax-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
InventorsAxel Ullrich, Johannes Bange, Pjotr Knyazev
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Abstract
The invention provides a method for the therapeutic treatment of a cancer in a mammal wherein (i) the mammal comprises a mutated fibroblast growth factor receptor-4 (FGFR-4) protein, and (ii) the mutated FGFR-4 comprises at least one point mutation in the transmembrane domain of FGFR-4 that substitutes a hydrophilic amino acid for a hydrophobic amino acid. The method comprises administering to the mammal an effective amount of at least one inhibitor of the mutated FGFR-4.
Claims11
A method for the therapeutic treatment of a carcinoma in a mammal wherein (i) the mammal comprises a mutated fibroblast growth factor receptor-4 (FGFR-4) protein, and (ii) the mutated FGFR-4 protein comprises the amino acid sequence of SEQ ID NO:
- 9 except that glycine at position 388 of SEQ ID NO:
- 9 has been substituted with arginine, which method comprises administering to the mammal an effective amount of at least one inhibitor of the mutated FGFR-4 selected from the group consisting of an anti-FGFR-4 antibody and a kinase inactive FGFR-4, whereby the carcinoma in the mammal is treated.
A method for the therapeutic treatment of a carcinoma in a mammal wherein (i) the mammal comprises a mutated fibroblast growth factor receptor-4 (FGFR-4) protein, and (ii) the mutated FGFR-4 protein comprises the amino acid sequence of SEQ ID NO:
- 9 except that glycine at position 388 of SEQ ID NO:
- 9 has been substituted with arginine, which method comprises administering to the mammal an effective amount of an anti-FGFR-4 antibody, whereby the carcinoma in the mammal is treated.
Dependencies are inferred from the claim text.