US 7,678,249 B2Granted

Instrument and system for pharmacologic measurement and well vessel used therein

AssigneePanasonic Corporation

InventorsNobuhiko Ozaki, Hiroaki Oka

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Abstract

An instrument is provided for pharmacologic measurement capable of detecting a very small and short time change in electric signal caused by a pharmacologic action of a biologic specimen with quickness and a high sensitivity by steeply decreasing an external disturbance component mixed into the system while dropping/exchange of medicinal solutions is conducted in a batch mode. The pharmacologic measurement instrument detects a change in electric signal caused by a pharmacologic action or electrophysiologic action of a biologic specimen, and includes an electrically conductive box having an opening section at the top surface thereof, and a well vessel disposed in the opening section thereof, wherein the well vessel includes a base having recesses in which the biologic specimens are put; measurement electrodes formed on the bottom surfaces of the respective recesses; and reference electrodes electrically insulated from the respective measurement electrodes, and the reference electrodes together with the electrically conductive box electrostatically shields the well vessel.

Claims18

Dependent claims

A pharmacologic measurement instrument for detecting an electric signal caused by a pharmacologic action or electrophysiologic action of a biologic specimen, said pharmacologic measurement instrument comprising:

an electrically conductive box provided with an opening section;
and
a well vessel disposed in said opening section of said electrically conductive box,
wherein said well vessel comprises:
a base substrate having a top surface and a plurality of well recesses, said plurality of well recesses being configured to hold biologic specimens;
a plurality of measurement electrodes provided on bottom surfaces or back surfaces of respective well recesses of said plurality of well recesses;
and
a plurality of reference electrodes electrically insulated from respective measurement electrodes of said plurality of measurement electrodes, said plurality of reference electrodes being electrically connected to said electrically conductive box,
wherein said reference electrodes cover said top surface of said base substrate and extend into said plurality of well recesses such that an upper portion of each of said respective well recesses is covered and a lower portion of each of said respective well recesses is not covered.

6 more elements

Dependencies are inferred from the claim text.