Polyacrylamide hydrogel and its use as an endoprosthesis
AssigneeContura A/S
InventorsJens Petersen, Richard Schmidt, Robert Lessèl, Jens-Erik Sørensen
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Abstract
A biocompatible hydrogel comprises a specified content of polyacrylamide and pyrogen-free water. Also disclosed is a method of making the hydrogel and an injectable or implantable endoprosthesis. The hydrogel may also be used to treat a cosmetic or functional defect. Hydrogels specified according to their polyacrylamide content may be used for medical indications, such as an implantable or injectable endoprostheses for mammoplastic reconstruction, implantable or injectable endoprostheses for treating (reflux) oesophagitis, and for body contouring of various body parts.
Claims19
A bio-stable hydrogel for use as an endoprosthesis in a mammal, said hydrogel, prior to being administered as an endoprosthesis, consisting essentially of:
- a cross-linked polyacrylamide which includes a cross-linked polymer of acrylamide and methylene bis-acrylamide, wherein the acrylamide and methylene bis-acrylamide are combined in a molar ratio of 150:1 to 1000:1 and wherein the hydrogel comprises about 0.5 to less than 3.5% of the polyacrylamide by weight, based on the total weight of the hydrogel, and
- water or an aqueous solution,
- wherein the hydrogel comprises less than 50 ppm of acrylamide and methylene bis-acrylamide monomers;
- and wherein the hydrogel has an elasticity module from about 10 to 700 Pa and a complex viscosity from about 2 to 60 Pas,
- wherein the hydrogel is resistant to biological degradation, and
- wherein the hydrogel is not water-soluble.
A bio-stable hydrogel for use as an endoprosthesis in a mammal, said hydrogel, prior to being administered as an endoprosthesis, comprising:
- a cross-linked polyacrylamide which consists essentially of a cross-linked polymer of acrylamide and methylene bis-acrylamide, wherein the acrylamide and methylene bis-acrylamide are combined in a molar ratio of 150:1 to 1000:1 and wherein the hydrogel comprises about 0.5 to less than 3.5% of the polyacrylamide by weight, based on the total weight of the hydrogel, and
- water or an aqueous solution,
- wherein the hydrogel comprises less than 50 ppm of acrylamide and methylene bis-acrylamide monomers;
- and wherein the hydrogel has an elasticity module from about 10 to 700 Pa and a complex viscosity from about 2 to 60 Pas,
- wherein the hydrogel is resistant to biological degradation, and
- wherein the hydrogel is not water-soluble.
A bio-stable hydrogel for use as an endoprosthesis in a mammal, said hydrogel, prior to being administered as an endoprosthesis, comprising:
- about 0.5% to less than 3.5%, based on the total weight of the hydrogel, of a polymer consisting essentially of a cross-linked polyacrylamide and methylene bis-acrylamide, wherein the acrylamide and methylene bis-acrylamide are combined in a molar ratio of 150:1 to 1000:1, and
- at least 95% water or an aqueous solution,
- wherein the hydrogel comprises less than 50 ppm of acrylamide and methylene bis-acrylamide monomers;
- and wherein the hydrogel has an elasticity module from about 10 to 700 Pa and a complex viscosity from about 2 to 60 Pas,
- wherein the hydrogel is resistant to biological degradation, and
- wherein the hydrogel is not water-soluble.
Dependencies are inferred from the claim text.