Delivery device and method of delivery

An ophthalmic delivery device comprising:

• first means for defining a variable-volume chamber and for storing an ophthalmic substance to be delivered to an eye;
• second means for metering a dose of substance from the variable-volume chamber at a volume within the range of about 15 to about 25 micro liters and for pressurizing the metered dose above a valve opening pressure;
• third means in fluid communication with the second means for (i) forming a closed position defining a fluid-tight seal for preventing the passage of substance therethrough, and (ii) at least one open position for allowing a the metered dose of substance pressurized by the second means at a pressure greater than the valve opening pressure to flow therethrough;
• and
• fourth means for delivering the metered dosage in a plurality of micro droplets at a velocity exiting the third means of less than approximately 10 meters per second.

A method for delivering a substance to an eye, comprising:

• (i) storing multiple doses of the substance hermetically sealed in a variable-volume chamber connectible in fluid communication with a one-way valve defining a normally closed valve opening that opens in response to the substance at an inlet to the valve opening exceeding a valve opening pressure;
• (ii) metering a dose of substance from the variable-volume storage chamber at a volume within the range of about 15 micro liters to about 25 micro liters and pressurizing the metered dose above the valve opening pressure;
• (iii) introducing the pressurized metered dose through the one way valve;
• and
• (iv) delivering the metered dose from the one way valve in a plurality of micro droplets at a velocity of less than approximately 10 meters per second and into the eye.