Flow-independent parameter estimation based on tidal breathing exhalation profiles
AssigneeThe Regents of the University of California
InventorsSteven C. George, Peter Condorelli
Life of this patent
Estimating the term…
Abstract
Parametric characterization of nitric oxide (NO) gas exchange using a two-compartment model of the lungs is a non-invasive technique to characterize inflammatory lung diseases. The technique applies the two-compartment model to parametric characterization of NO gas exchange from a tidal breathing pattern. The model is used to estimate up to six flow-independent parameters, and to study alternate breathing patterns.
Claims11
A method of determining which flow-independent parameters of nitric oxide exchange in the lungs are characterized within an interval of acceptable accuracy during tidal breathing, comprising:
- having a subject perform a tidal breathing maneuver;
- measuring and recording NO concentration and flow rate simultaneously during the maneuver;
- simulating the tidal breathing maneuver by a two-compartment model;
- fitting recorded subject flow rate and exhaled NO concentration to results obtained from the simulating of the tidal breathing maneuver from the two-compartment model;
- and
- comparing in a processing or electronic device the recorded subject flow rate and exhaled NO concentration and the results obtained from the simulating of the tidal breathing maneuver to diagnose respiratory disease.
A method of diagnosing a respiratory disease by utilizing data gathered during tidal breathing, comprising:
- having a subject perform a tidal breathing maneuver;
- measuring and recording NO concentration and flow rate simultaneously during the maneuver;
- simulating the tidal breathing maneuver by a two-compartment model;
- fitting recorded subject flow rate and exhaled NO concentration to results obtained from the simulating of the tidal breathing maneuver from the two-compartment model;
- and
- comparing in a pg or electronic device the recorded subject flow rate and exhaled NO concentration and the results obtained from the simulating of the tidal breathing maneuver to diagnose a respiratory disease.
Dependencies are inferred from the claim text.