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AssigneePresident and Fellows of Harvard College
InventorsKenneth Jeffrey Hayworth, Amy Au Hayworth
Estimating the term…
An automatic taping lathe-microtome that produces a continuous ribbon of tissue by lathing an extremely thin strip off the surface of a cylindrical block containing a multitude of embedded tissue samples. Mechanisms are included for sandwiching this fragile ribbon of tissue between a pair of support tapes. Viewing holes are cut in the support tapes above and below each tissue slice such that the tapes act as slot grids allowing for direct viewing of each tissue slice in a transmission electron microscope (TEM). The resulting tissue-tape is placed on a spooling mechanism and fed into the beam of a TEM much like the film in a movie projector. This allows for random-access imaging of any section on the tape without requiring the TEM's vacuum be broken. This system is intended to give neuroscientists a tool to ultrastructure image large volumes of neural tissue and to trace multi-scale synaptic circuits.
A method for the automatic production and collection of a plurality of thin sections of tissue from a plurality of biological tissue samples, comprising:
A method, comprising:
A method for processing at least one tissue sample, the method comprising:
Dependencies are inferred from the claim text.