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US 7,676,329 B2Granted
Method and system for processing multi-dimensional measurement data
AssigneeRoche Diagnostics Operations, Inc.
InventorsUrsula Garczarek, Pavel Kubalec, Wolfgang Hösel
Life of this patent
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Abstract
The invention provides a method for grouping measurement data obtained by effecting two or more techniques to provide characterization data characterizing at least one sample with respect to characterizing substances. According to one aspect of the invention, the grouping is effected on the basis of at least one statistical distribution of deviations (Δm/zi) of a respective characterizing measurement value. According to another aspect of the invention, the grouping is effected on the basis of at least one collective characteristic of a plurality of respective quantitative measurement values (Ii).
Claims31
A method for analyzing a sample to provide characterization data with respect to at least one constituent of a sample, the method comprising:
- (a) in an analyzing system, effecting at least one first analytical technique selected from the group of separation techniques including (i) separation of constituents of the sample, (ii) separation of products resulting from a first analytical technique, and (iii) separation of constituents of the sample and products resulting from a first analytical technique, wherein the constituents include any combination selected from the group consisting of (i) chemical constituents, (ii) biological constituents, and (iii) biochemical constituents, and
- wherein the separation techniques are effected with respect to at least one first differentiating characteristic of constituents or products;
- (b) in the analyzing system, effecting a further analytical technique with respect to constituents or products already separated or in the process of being separated,
- wherein the further analytical technique is an analytical and detection technique for characterizing separated constituents or products using at least one basis selected from said group including a product resulting from a first analytical technique and a further differentiating characteristic,
- wherein the analyzing system further comprises detection hardware providing measurement data in terms of at least two characterizing measurement quantities, namely a first quantity of the characterizing measurement quantities reflecting a product obtained from effecting step (a) at least once and a second quantity of the characterizing measurement quantities reflecting at least one of said group including a product obtained from effecting step (a) at least once and the further differentiating characteristic;
- (c) in a data processing system having a processor and associated data storage, storing in the data storage a plurality data tuples for associating a first value associated with the first quantity of the characterizing measurement quantities with a second value associated with the second quantity of the characterizing measurement quantities;
- (d) with the said data processing system, grouping the data tuples into intervals according to at least one of the characterization measurement value, wherein the intervals are each associated with a particular one of the constituents or products, wherein said grouping is based on a statistical distribution of deviations from a characteristic value associated with the constituents or products;
- and
- (e) with the said data processing system providing an output of data reflecting a data set indicative of the data tuples or a visualization of the data set, wherein the providing of the output of data comprises a step selected from the group of steps consisting of storing data in said data storage, displaying data on a display screen, and printing data.
6 more elements
A system for analyzing a sample by effecting two or more techniques to provide characterization data with respect to a constituent comprising:
- (a) a first analyzing unit for effecting at least one first analytical technique selected from the group of separation techniques including (i) separation of constituents of the sample, (ii) separation of products resulting from a first analytical technique, and (iii) separation of constituents of the sample and products resulting from a first analytical technique, wherein the constituents include any combination selected from the group including (i) chemical constituents, (ii) biological constituents, and (iii) biochemical constituents, and wherein the separation techniques are effected with respect to at least one first differentiating characteristic of constituents or products;
- (b) a further analyzing unit for effecting a further analytical technique with respect to constituents or products already separated or in the process of being separated, wherein the further analytical technique is an analytical and detection technique for characterizing separated constituents or products using at least one basis selected from the group including a product resulting from a first analytical technique and a further differentiating characteristic, the further analyzing unit includes detection hardware for providing measurement data in terms of at least two characterizing measurement quantities, a first quantity of the characterizing measurement quantities reflecting a product obtained from effecting step (a) at least once and a second quantity of the characterizing measurement quantities reflecting at least one of the group including a product obtained from effecting step (a) at least once and the further differentiating characteristic;
- (c) a control unit having at least a processor and associated data storage,
- (d) program logic stored in data storage and executable by the processor for:
- (i) providing a plurality data tuples for associating the first quantity of the characterizing measurement quantities with the second quantity of the characterizing measurement quantities;
- (ii) grouping the data tuples into intervals according to at least one of the characterization measurement quantities, wherein the intervals are each associated with a particular one of the constituents or products, wherein grouping is based on a statistical distribution of deviations from a characteristic value associated with the constituents or products;
- and (iii) providing an output of data reflecting a data set indicative of the data tuples or a visualization of the data set, wherein the output of data comprises a step selected from the group including storing data in a data storage, displaying data on a display screen, and printing data.
4 more elements
A method for analyzing a sample to provide characterization data with respect to at least one constituent of a sample, the method comprising:
- (a) receiving at least two characterizing measurement quantities, a first quantity of the characterizing measurement quantities reflecting a product obtained from a first analytical technique performed on the sample at least once and a second quantity of the characterizing measurement quantities reflecting a product obtained from a further analytical technique performed with respect to constituents or products of the sample;
- (b) generating a plurality data tuples for associating the first quantity of the characterizing measurement quantities and the second quantity of the characterizing measurement quantities;
- and
- (c) grouping the data tuples into intervals according to at least one of the characterizing measurement quantities, wherein the intervals are each associated with a particular one of the constituents or products of the sample, wherein the grouping is based on a statistical distribution of deviations from a characteristic value associated with the constituents or products;
- wherein steps (a), (b) and (c) are performed in a data processing system having a processor and associated data storage.
2 more elements
Dependencies are inferred from the claim text.