Bridged aromatic substituted amine ligands with donor atoms

A compound of the formula:

• wherein:
• n=0 or 1;
• R1 and R2 are independently selected from hydrogen, ═O, with the proviso that both are not ═O, —(CH2)m—Z where m is 0-10 and Z represents a conjugation group or targeting moiety, and —(CH2)m—W where m is 0-10 and W represents a hydrolyzable group, or R1 and R2 are taken together to form a cyclic anhydride or a benzene ring, wherein the benzene ring is optionally substituted with a carboxyl group;
• R3 is hydrogen, lower alkyl, alkoxy, halogen, hydroxyl, nitro, —(CH2)m—Z or —(CH2)m—W;
• R4 and R5 are attached at one or more of the ring positions and are independently selected from hydrogen, lower alkyl, alkoxy, halogen, hydroxyl, nitro, —(CH2)m—Z and —(CH2)m—W;
• R6 and R7 are independently selected from hydrogen with the proviso that both are not hydrogen, lower alkyl, alkoxy, halogen, hydroxyl, nitro, —(CH2)m—Z, —(CH2)m—W— and
• where Q represents a multivalent acid functionality group able to coordinate with metal ions, and p=0 to 1;
• R12 and R13 are independently selected from hydrogen, hydroxyl, carboxyl, phosphoric, and hydrocarbon radicals having from 1-10 carbon atoms, and physiologically acceptable salts of the acid radicals;
• X, X′, and Y and Y′ are independently selected from carbon and nitrogen to independently form 5 member aromatic rings wherein the remaining ring atoms are carbon;
• A and A′ are independently selected from sulfur, nitrogen and oxygen, where sulfur may bear a hydrogen or a sulfur protecting group, or where A and A′ are both sulfur, A and A′ may be joined together by a bond;
• where an oxygen or a nitrogen may bear a hydrogen;
• or where A or A′ is nitrogen, A may bear R8 or R10 or both and A′ may bear R9 or R11 or both, wherein R8, R9, R10 and R11 are independently selected from lower alkyl, alkoxy, halogen, hydroxyl, nitro, —(CH2)m—Z, —(CH2)m—W and
• or R8 and R10 may be joined to form a cyclic anhydride or R9 and R11 may be joined to form a cyclic anhydride;
• or when A and A′ are both nitrogen, R10 and R11 are joined to form T, where T is
• and n is 0 to 1, and R1′ and R2′ are independently selected from hydrogen, ═O, with the proviso that both are not ═O, —(CH2)m—Z, or R1′ and R2′ are taken together to form a cyclic anhydride or a benzene ring, wherein the benzene ring is optionally substituted with a carboxyl group;
• and R3′ is hydrogen, lower alkyl, alkoxy, halogen, hydroxyl, nitro, —(CH2)m—Z or —(CH2)m—W;
• and
• the compound has at least one Z, W or Q.