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AssigneesTrustees of Tufts College, Massachusetts Institute of Technology
InventorsDavid L. Kaplan, Hyoung-Joon Jin, Gregory Rutledge, Sergey Fridrikh
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The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.
A tissue engineered construct comprising a non-woven network of electrospun fibers and a mammalian cell, wherein said fibers comprise silk fibroin and a biocompatible polymer wherein said tissue engineered construct is produced by the steps of:
A process for producing a silk blend film, comprising the steps of:
A method of preparing a silk biomaterial scaffold comprising the steps of:
A composition comprising an aqueous solution of a silk fibroin obtained from silkworm silk or spider silk and biocompatible polymer, wherein the composition is free of solvents other than water.
A fiber produced by a process comprising the steps of:
A method of producing a synthetic fiber comprising the steps of:
A method of producing a synthetic fiber comprising the steps of:
Dependencies are inferred from the claim text.