2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity for the treatment of asthma and other inflammatory or immunological disorders

A compound of the formula (I), its tautomeric or stereoisomeric form, or a physiologically acceptable salt thereof:

• wherein
• X represents O or S;
• R1 represents hydrogen, halogen, hydroxy, nitro, cyano, C1-6 alkoxy carbonyl, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, C1-6 alkanoyl, phenyl, C1-6 alkyl optionally substituted by mono-, di- or tri-halogen, or C1-6 alkoxy optionally substituted by mono-, di- or tri-halogen;
• R2 represents hydrogen, halogen, hydroxy, nitro, cyano, C1-6 alkoxy carbonyl, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, C1-6 alkanoyl, phenyl, C1-6 alkyl optionally substituted by mono-, di- or tri-halogen, or C1-6 alkoxy optionally substituted by mono-, di- or tri-halogen;
• R3 represents hydrogen, halogen, hydroxy, nitro, cyano, amino, carboxy, tetrazolyl, C1-6 alkoxy, C1-6 alkoxycarbonyl, C1-6 alkanoyl, C1-6 alkanoylamino, C1-6 alkyl optionally substituted by mono-, di- or tri-halogen or hydroxy;
• R4 represents
• wherein:
• R71 represents hydrogen, or C1-6 alkyl optionally substituted by amino, hydroxy, carboxy, pyrrolidinyl or piperidinyl, wherein said pyrrolidinyl and piperidinyl are optionally substituted by mono- or di-oxo;
• R72 represents hydrogen, carboxy, C1-6 alkanoyl, amino, (C1-6alkyl)amino, di(C1-6alkyl)amino, N-(C1-6alkyl)amino carbonyl, C1-6 alkyl optionally substituted by hydroxy, carboxy, or mono-, di- or tri-halogen, C1-6 alkoxy optionally substituted by mono-, di- or tri-halogen, pyrrolidinyl or piperidinyl, wherein said pyrrolidinyl and piperidinyl are optionally substituted by mono- or di-oxo;
• and
• Z1 represents —[CH2]p—, wherein p is 2.