Oxygen sensitive probe
AssigneeLuxcel Biosciences Limited
InventorsDmitri Boris Papkovsky, Richard Fernandes
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Abstract
An oxygen sensitive probe comprises a monofunctional derivative of an oxygen-sensitive photoluminescent dye covalently attached to a water soluble and/or hydrophilic macromolecular carrier. The probe may be a chemical conjugate of a monofunctional phosphorescent porphyrin dye and a poly(ethyleneglycol), polypeptide or polysaccharide.
Claims63
An oxygen sensitive probe comprising a monofunctional derivative of an oxygen sensitive photoluminescent dye covalently attached to a water soluble hydrophilic macromolecular carrier selected from the group comprising a polypeptide, a polysaccharide, and a poly(ethyleneglycol), the oxygen-sensitive photoluminescent dye including a single reactive chemical group for chemical conjugation to the macromolecular carrier and the oxygen sensitive photoluminescent dye being a monofunctional p-isothiocyantophenyl derivative of Pt-coproporphyrin-I.
An oxygen sensitive probe comprising a monofunctional derivative of an oxygen sensitive photoluminescent dye covalently attached to a water soluble hydrophilic macromolecular carrier selected from the group comprising a polypeptide, a polysaccharide, and a poly(ethyleneglycol), the oxygen sensitive photoluminescent dye including a single reactive chemical group for chemical conjugation to the macromolecular carrier and the oxygen sensitive photoluminescent dye being a monofunctional amino, maleimido-, or N-succinimido-derivative of Pt-coproporphyrin-I.
An oxygen sensitive probe comprising a monofunctional derivative of an oxygen sensitive photoluminescent dye covalently attached to a water soluble hydrophilic macromolecular carrier, the macromolecular carrier including poly (ethyleneglycol) (PEG) having a molecular mass exceeding 2,000 Da.
Dependencies are inferred from the claim text.