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US 7,674,346 B2Granted
Multi-well plate and method of manufacture
AssigneeCorning Incorporated
InventorsJames G. Clements, Michael Curtis, Paul E. Gagnon, William J. Lacey, Gregory R. Martin, David M. Root, Allison J. Tanner
Life of this patent
Estimating the term…
Abstract
A method of manufacture and assembly of multiwell plates employing targeted radiation at an interface in order to achieve bonding is disclosed. The method accommodates glass and polymer attachment as well as polymer to polymer attachment. Resultant plates have unique flatness and optical properties.
Claims27
A method of making a multiwell plate comprising the steps of:
- providing an upper plate having an array of open ended wells, said upper plate being formed from an organic polymeric material having a predetermined melting temperature and comprising a silane functional polymer;
- providing a substantially flat transparent lower plate, said lower plate being comprised of an inorganic material;
- contacting said upper plate to said lower plate at an interface;
- heating said upper plate at said interface to the melting temperature of said polymeric material;
- and whereby said upper plate and said lower plate are bonded together.
2 more elements
A method of making a multiwell plate comprising the steps of:
- providing an upper plate having an array of open ended wells, said upper plate being formed from an organic polymeric material comprising a silane functional polymer having a predetermined melting temperature;
- providing a substantially flat transparent lower plate, said lower plate comprising of an inorganic material;
- heating said lower plate to the melting temperature of said polymeric material;
- contacting said upper plate to said lower plate at an interface whereby said upper plate and said lower plate are bonded together.
1 more element
A method of making a multiwell plate comprising the steps of:
- providing an upper plate having an array of open ended wells, said upper plate being formed from an organic polymeric material having a predetermined melting temperature, said upper plate further containing a plurality of metallic flecks integrally blended therethrough;
- providing a substantially flat transparent lower plate, said lower plate being comprised of an inorganic material;
- contacting said upper plate to said lower plate at an interface;
- directing a beam of electromagnetic radiation to the upper plate at said interface through said lower plate and thereby heating said upper plate to the melting temperature of said polymeric material;
- wherein the organic polymeric material is a silane functional polymer;
- and,
- whereby said upper plate and said lower plate are bonded together.
4 more elements
A method of making a multiwell plate comprising the steps of:
- providing an upper plate having an array of open ended wells, said upper plate being formed from an organic polymeric material having a predetermined melting temperature;
- providing a lower plate, said lower plate comprising an organic polymeric material having a predetermined melting temperature;
- providing an infra red radiation absorbing layer in the form of a gasket, a layer on a bottom surface of the upper plate, or a layer on a top surface of the lower plate;
- contacting said upper plate to said lower plate, with said infra-red radiation-absorbing layer therebetween;
- and
- heating said infra red radiation absorbing layer to the melting temperature of either the polymeric material of the lower plate, the polymeric material of the upper plate, or both;
- and whereby said upper plate and said lower plate are bonded together.
4 more elements
A method of making a multiwell plate comprising the steps of:
- providing an upper plate having an array of open ended wells, said upper plate being formed from an organic polymeric material having a predetermined melting temperature;
- providing a lower plate, said lower plate being comprised of an organic polymeric material having a predetermined melting temperature;
- providing an electromagnetic radiation absorbing layer in the form of a gasket between said upper plate and said lower plate;
- heating said electromagnetic radiation absorbing layer to the melting temperature of either the polymeric material of the lower plate, the polymeric material of the upper plate, or both;
- and
- whereby said upper plate and said lower plate are bonded together.
3 more elements
Dependencies are inferred from the claim text.