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US 7,670,817 B2Granted
Dynamin mediated diseases and associated methods and products
AssigneeThe General Hospital Corporation
InventorsJochen Reiser, Sanja Sever
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Abstract
This invention relates generally to the treatment of cathepsin or dynamin mediated diseases, such as proteinuria, cancer, and cognitive disease and related products. Diagnostic and other assays are also provided, as well as methods for podocyte cell gene transfer.
Claims5
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1, wherein the isolated polypeptide contains at least one mutation rendering it resistant to proteolytic-cleavage but does not impair its ability to form actin stress fibers in podocytes, wherein said at least one mutation is L356Q or G358V.
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1, wherein the isolated polypeptide contains the mutation R725A.
Dependencies are inferred from the claim text.