Modified soluble T cell receptor
AssigneeImmunocore Limited
InventorsBent Karsten Jakobsen, Meir Glick
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Abstract
The present invention provides a soluble T cell receptor (sTCR), which comprises (i) all or part of a TCR $g(a) chain, except the transmembrane domain thereof, and (ii) all or part of a TCR $g(b) chain, except the transmembrane domain thereof. (i) and (ii) each comprise a functional variable domain and at least a part of the constant domain of the TCR chain, and are linked by a disulphide bond between constant domain residues which is not present in native TCR, characterized in that the sTCR recognizes a CD1-antigen complex, a bacterial superantigen or a peptide-MHC/superantigen complex.
Claims19
A soluble T cell receptor (sTCR), which comprises (i) all or part of a TCR α chain, except the transmembrane domain thereof, and (ii) all or part of a TCR β chain, except the transmembrane domain thereof, wherein (i) and (ii) each comprise a variable domain and at least a part of the constant domain of the TCR chain, and are linked by a disulphide bond between constant domain cysteine residues substituted for Thr 48 of exon 1 of TRAC*01 and Ser 57 of exon 1 of TRBC1*01 or TRBC2*01, wherein Thr 48 is amino acid 10 of SEQ ID NO:1 and wherein Ser 57 is amino acid 10 of SEQ ID NO:5 characterized in that the sTCR binds a CD1-antigen complex, wherein one or both of (i) and (ii) comprise all of the extracellular constant immunoglobulin domain of the TCR chain.
Dependencies are inferred from the claim text.