Back to results
US 7,666,408 B2Granted
Angiotensin peptide-carrier conjugates and uses thereof
AssigneeCytos Biotechnology AG
InventorMartin Bachmann
Life of this patent
Estimating the term…
Abstract
The present invention provides conjugates of peptide derivatives of the mammalian peptide hormones angiotensinogen, angiotensin I and angiotensin II, presented in a repetitive scaffold by coupling the peptide derivatives to a carrier, particularly a virus-like particle (VLP). The invention also provides methods of producing such conjugates, and immunotherapeutic uses of the resulting immunogen conjugates for the therapy and prophylaxis of conditions associated with the renin-activated angiotensin system.
Claims21
An angiotensin peptide moiety-carrier conjugate comprising:
- (a) a carrier with at least one first attachment site;
- and
- (b) at least one angiotensin peptide moiety with at least one second attachment site,
- wherein said carrier comprises a core particle that is a virus-like particle of an RNA-bacteriophage and,
- wherein said second attachment site is capable of association through at least one non-peptide covalent bond to said first attachment site so as to form an ordered and repetitive angiotensin peptide moiety-carrier conjugate, and wherein said angiotensin peptide moiety with said second attachment site consists of the amino acid sequence CGGDRVYIHPF (SEQ ID NO:
- 19).
3 more elements
Dependencies are inferred from the claim text.