Glycosyltransferase GnT-V having neovascularization action
AssigneeSuntory Holdings Limited
InventorsNaoyuki Taniguchi, Eiji Miyoshi, Takashi Saito
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Abstract
The present invention provides a peptide or protein having a neovascularization action and containing a basic amino acid cluster region of β1,6-N-acetylglucosaminyltransferase, a neovascularization accelerator containing the above-mentioned peptide or protein, a method of screening an inhibition substance for the above-mentioned peptide or protein, and a neovascularization inhibitor containing this inhibition substance.
Claims9
An isolated polypeptide fragment of an N-acetylglucosaminyltransferase V (GnT-V), comprising a basic amino acid cluster region,
- wherein the basic amino acid cluster region comprises the amino acid sequence of SEQ ID NO:
- 7 and up to 50 contiguous amino acids encoded by the sequence shown in SEQ ID NO:
- 6, or a variant thereof,
- wherein the polypeptide fragment or variant thereof possesses neovascularization activity,
- wherein the number of amino acids modified by addition, removal, or substitution in the variant is up to 10% of the number of amino acids in the basic amino acid cluster region, and
- wherein the addition, removal, or substitution is conducted on amino acids other than basic amino acids.
A pharmaceutical composition comprising an amount of an isolated polypeptide consisting of SEQ ID NO:
- 7 sufficient to accelerate neovascularization.
Dependencies are inferred from the claim text.