US 7,662,409 B2 · Protein matrix materials, devices and methods of making and using thereof

Abstract

The present invention relates to protein matrix materials and devices and the methods of making and using protein matrix materials and devices. More specifically the present invention relates to protein matrix materials and devices that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, encapsulated or coated stent devices, vessels, tubular grafts, vascular grafts, wound healing devices including protein matrix suture material and meshes, skin/bone/tissue grafts, biocompatible electricity conducting matrices, clear protein matrices, protein matrix adhesion prevention barriers, cell scaffolding and other biocompatible protein matrix devices. Furthermore, the present invention relates to protein matrix materials and devices made by forming a film comprising one or more biodegradable protein materials, one or more biocompatible solvents and optionally one or more pharmacologically active agents. The film is then partially dried, rolled or otherwise shaped, and then compressed to form the desired protein matrix device.

Claims66

Dependent claims

A solvated compressed protein matrix material, comprising one or more biocompatible protein materials, combined with one or more biocompatible solvents and optionally one or more pharmacologically active agents, wherein the protein material(s), biocompatible solvent(s) and optional pharmacologically active agent(s) are formed into a cohesive solid body having a solvent content of about 20% to 80% and not having the characteristics of cracking, shattering, breaking or being crosslinked so as to inhibit the cohesive solid body from remaining cohesive unto itself when being formed and the cohesive solid body is compressed at a pressure of about 100 psi to 100,000 psi to remove bulk biocompatible solvent and generate additional intermolecular and Intramolecular forces between one or more of the protein material(s), solvent(s) and/or pharmacologically active agent(s) to form the solvated compressed protein matrix material having a solvent content of about 10% to 60%.

A method of delivery of one or more pharmacologically active agents, cells or a combination thereof comprising:

providing a drug delivery device comprising one or more biocompatible protein materials, combined with one or more biocompatible solvents and one or more pharmacologically active agents, cells or combinations thereof, wherein the protein material(s), biocompatible solvent(s) and pharmacologically active agent(s), cells or combinations thereof are formed into a cohesive solid body having a solvent content of about 20% to 80% and not having the characteristics of cracking, shattering, breaking or being crosslinked so as to inhibit the cohesive solid body from remaining cohesive unto itself when being formed and the cohesive solid body is compressed at a pressure of about 100 psi to 100,000 psi to remove bulk biocompatible solvent and generate additional intermolecular and intramolecular forces between one or more of the protein material(s), solvent(s) and/or pharmacologically active agent(s) to form the drug delivery device having a solvent content of about 10% to 60%;
and
administering the drug delivery device to a patient.

Dependencies are inferred from the claim text.

Protein matrix materials, devices and methods of making and using thereof

Life of this patent

Protein matrix materials, devices and methods of making and using thereof

Life of this patent

Abstract

Claims66