Use of glucose-6-phosphate isomerase and antibodies thereto for the diagnosis and therapy of arthritis, and test of anti-arthritic compounds
AssigneeInstitut National De La Sante Et De La Recherche Medicale (Inserm)
InventorsChristophe Benoist, Isao Matsumoto, Anne-Sophie Korganow, Diane Mathis, Mariana Maccioni, Hong Ji
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Abstract
The present invention relates to the use of antibodies against glucose-6-phosphate isomerase (GPI) and like protein for diagnosis of arthritis and the use of said protein for treatment of arthritis. It is also aimed at a process for isolating monoclonal antibodies capable of transferring arthritis and antibodies thereof, as well as a method for determining the anti-arthritis potential of a composition.
Claims1
A method comprising injecting arthritic K/BxN transgenic mouse serum into a mouse, wherein the injected mouse develops arthritis.
Dependencies are inferred from the claim text.