Back to results
US 7,659,317 B2Granted
Methods to prepare carbon-isotope labeled organohalides with high specific radioactivity from carbon-isotope monoxide
AssigneeGe Healthcare Limited
InventorsJonas Eriksson, Bengt Langstrom, Gunnar Antoni
Life of this patent
Estimating the term…
Abstract
Methods and reagents for labeling synthesis of organohalides by transition metal mediated carbonylation reactions using carbon-isotope labeled carbon monoxide are provided. The resultant carbon-isotope labeled organohalides are useful as radiopharmaceuticals, especially for use as precursors in Positron Emission Tomography (PET). Associated PET tracers and kits for PET studies are also provided.
Claims13
A method for labeling synthesis of organohalides, comprising:
- (a) providing a high pressure reaction chamber having a liquid/gas inlet and a gas inlet in a bottom surface thereof,
- (b) providing a substrate solution to be labeled mixed with a transition metal complex,
- (c) providing H2 gas or HOR, with optional water, where R is independently linear or lower cyclic alkyl or aryl,
- (d) introducing a carbon-isotope monoxide enriched gas-mixture into the reaction chamber via the gas inlet,
- (e) introducing at high-pressure said H2 gas or HOR, with optional water, into the reaction chamber via the liquid/gas inlet,
- (f) introducing at high-pressure said substrate solution mixed with transition metal complex into the reaction chamber via the liquid/gas inlet,
- (g) waiting a predetermined time while the labeling synthesis occur, and
- (h) removing the labeled compounds from the reaction chamber,
- (i) reducing the labeled compounds to alcohol,
- (j) substituting with a halogen atom to obtain the labeled organohalides.
7 more elements
Dependencies are inferred from the claim text.