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US 7,658,919 B2Granted
Compositions and methods for inhibiting H. pylori adhesion and infection
AssigneeRecopharma AB
InventorsJan Holgersson, Jining Liu, Anki Gustafsson, Jonas Lofling
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Abstract
The present invention provides compositions and methods for treating or preventing bacterial infections. Also provide by the invention are genetically modified cell expressing Lewisb carbohydrate epitope.
Claims12
A fusion polypeptide comprising a first polypeptide operably linked to a second polypeptide, wherein the first polypeptide is glycosylated
- a. on O-linked glycans by an α1,¾ fucosyltransferase, an α1,2 fucosyltransferase, a β1,3 galactosyltransferase and a β 1,3, N-acetylglucosaminyltransferase, or
- b. on N-linked glycans by an α1,¾ fucosyltransferase, an α1,2 fucosyltransferase and a β1,3 galactosyltransferase;
- and
- c. comprises multiple Leb epitopes;
- and the second polypeptide comprises at least a region of an immunoglobulin polypeptide.
2 more elements
Dependencies are inferred from the claim text.