Therapeutic and diagnostic cloned MHC-unrestricted receptor specific for the MUC1 tumor associated antigen
AssigneeUniversity of Pittsbugh — Of the Commonwealth System of Higher Education
InventorsOlivera J. Finn, Nehad M. Alajez, Jan Schmielau, Mark D. Alter
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Abstract
The invention provides an isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC1 tumor antigen independently of an major histocompatibility complex (MHC). The invention provides a method of activating a signaling pathway and/or killing a cancer cell using a receptor that is similar to or is a T cell receptor.
Claims3
An isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC 1 tumor antigen independently of a major histocompatibility complex (MHC), wherein the receptor
- a. has a first amino acid sequence comprising the sequence of the complementarity determining regions (CDRs) of MA Vα23 shown in FIG. 1 (SEQ ID NO:1), and
- b. has a second amino acid sequence comprising the sequence of the complementarity determining regions (CDRs) MA Vβ8.3 shown in FIG. 1 (SEQ ID NO:2).
An isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC 1 tumor antigen independently of a major histocompatibility complex (MHC), wherein the receptor comprises a portion of the zeta-chain of CD3.
Dependencies are inferred from the claim text.