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US 7,655,428 B2Granted
Latent protein C assays and their uses for diagnosis and/or prognosis in systemic inflammatory response syndromes
AssigneeBiosite, Inc.
InventorsGunars E. Valkirs, Joseph A. Buechler, Seok-Won Lee, Uday Kumar Veeramallu
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Abstract
The present invention relates to methods and compositions for measuring latent protein C in test samples, particularly patient samples. The methods and compositions described are sensitive for latent protein C, relative to activated protein C.
Claims23
An immunoassay method for detection of latent protein C in a sample of bodily fluid obtained from a patient, comprising:
- contacting the sample of bodily fluid with an antibody that specifically binds to latent protein C, wherein the antibody does not significantly cross-react with activated protein C, and wherein the antibody is a monoclonal antibody that competes with an antibody comprising a heavy chain variable region having an amino acid sequence of SEQ ID NO:6 and a light chain variable region having an amino acid sequence of SEQ ID NO:7 for specific binding to latent protein C;
- detecting an amount of antibody bound to latent protein C present in the sample;
- and
- calculating the amount of latent protein C present in the sample based on the amount of antibody detected.
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Dependencies are inferred from the claim text.