Chlamydia protein, gene sequence and uses thereof
AssigneeEmergent Product Development Gaithersburg Inc.
InventorsW. James Jackson, John L. Pace
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Abstract
A high molecular weight (“HMW”) protein of Chlamydia, the amino acid sequence thereof, and antibodies that specifically bind the HMW protein are disclosed as well as the nucleic acid sequence encoding the same. Also disclosed are prophylactic and therapeutic compositions, comprising the HMW protein, a fragment thereof, or an antibody that specifically binds the HMW protein or a portion thereof, or the nucleotide sequence encoding the HMW protein or a fragment thereof, including vaccines.
Claims26
A method of inducing an immune response against Chlamydia trachomatis comprising administering to a host in need thereof an effective amount of a composition, which comprises an isolated polypeptide comprising an amino acid sequence at least 95% identical to:
- (a) amino acids 29-1012 of SEQ ID NO:
- 2 or
- (b) amino acids 29-533 of SEQ ID NO:
- 2;
- and a carrier, wherein said administration induces an antibody response against said polypeptide.
Dependencies are inferred from the claim text.