Method and apparatus for glucose control and insulin dosing for diabetics

A run-to-run control method of deriving the optimal dosage of insulin to provide both the basal insulin requirement and the meal-related insulin dosing of an individual having diabetes, comprising:

• determining an insulin sensitivity matrix for said individual;
• measuring a postprandial glucose response to at least one meal;
• and
• estimating a preprandial dosage of insulin for a subsequent cycle's corresponding meal based on said insulin sensitivity matrix of said individual and measured postprandial glucose response to the meal and preprandial dose of insulin for a current cycle;
• wherein each element of said insulin sensitivity matrix is a function of one or more parameters affecting insulin needs of an individual pertaining to said individual;
• wherein said one or more parameters is selected from the group consisting of physical stress, psychological stress, hormonal stress, activity, fitness, and weight;
• wherein said insulin sensitivity matrix reflects a breadth of output responses in said individual as a function of changes in input;
• and
• wherein dosage amount for a subsequent cycle is higher than, lower than, or the same as, dosage amount for a current cycle.