US 7,645,813 B2Granted

Pressure-sensitive adhesive for the skin and tapes or sheets for the skin made by using the same

AssigneeCosmed Pharmaceutical Co., Ltd.

InventorMinoru Kohara

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Abstract

The invention provides a pressure-sensitive adhesive for the skin excellent in pressure-sensitive adhesiveness to the human skin and repeelability therefrom, which does not cause the horny layer to be torn away in peeling and is lowly irritant to the skin; and tapes or sheets made by using the same. The pressure-sensitive adhesive is characterized by comprising (a) 100 parts by weight of a copolymer which is prepared from an olefinic macromonomer and a vinyl monomer and whose molecular weight (in terms of polystyrene and as determined by gel permeation chromatography (GPC)) has a two-peak distribution (with the proviso that when the copolymer is to be post-cured, the distribution is one as determined before the post cure) and (b) 20 to 250 parts by weight of a softener which is compatible with the copolymer and liquid or pasty at room temperature and has a boiling point of 250 or above (with the proviso that when the content of the softener (b) exceeds 80 parts by weight, the copolymer must be post-cured).

Claims7

Dependent claims

A transdermal pressure-sensitive adhesive comprising:

(a) 100 parts by weight of a copolymer prepared by a process of solution polymerization involving simultaneous polymerization of four monomers including an olefinic macromonomer selected from the group consisting of polyethylene, polypropylene, ethylene-propylene copolymer, and ethylene-butylene copolymer, alkyl (meth)acrylate, at least one first vinyl monomer selected from the group consisting of n-vinyl-2-pyrrolidone, vinyl acetate and alkoxyalkyl (meth) acrylate, and a second vinyl monomer having a functional group selected from the group consisting of hydroxyl group, carboxyl group, glycidyl group, and amino group, said copolymer consisting of:
20 to 65% by weight of said olefinic macromonomer,
20 to 40% by weight of said alkyl (meth)acrylate,
10 to 40% by weight of said first vinyl monomer
and 0.5 to 25% by weight of said second vinyl monomer, thereby forming a random copolymer from these monomers, said copolymer having a molecular weight (in terms of polystyrene and as determined by gel permeation chromatography (GPC)) with a two-peak distribution (with the proviso that when the copolymer is to be post-cured, the distribution is one as determined before the post cure), and
(b) 20 to 250 parts by weight of a softener which is compatible with the copolymer and liquid or pasty at room temperature and has a boiling point of 250° C. or above (with the proviso that when the content of the softener (b) exceeds 80 parts by weight, the copolymer must be post- cured).

3 more elements

A transdermal pressure-sensitive adhesive composition comprising:

(1) a pressure-sensitive adhesive comprising;
(a) 100 parts by weight of a copolymer which is prepared by a process of solution polymerization involving simultaneous polymerization of four monomers including an olefinic macromonomer selected from the group consisting of polyethylene, polypropylene, ethyl-propylene copolymer, and ethylene-butylene copolymer, alkyl (meth)acrylate, at least one first vinyl monomer selected from the group consisting of n-vinyl-2-pyrrolidone, vinyl acetate and alkoxyalkyl (meth)acrylate, and a second vinyl monomer having a functional group selected from the group consisting of hydroxyl group, carboxyl group, glycidyl group, and amino group, said copolymer consisting of:
20 to 65% by weight of said olefinic macromonomer,
20 to 40% by weight of said alkyl (meth)acrylate,
10 to 40% by weight of said first vinyl monomer
and 0.5 to 25% by weight of said second vinyl monomer,
thereby forming a random copolymer from these monomers, said copolymer having a molecular weight (in terms of polystyrene and as determined by gel permeation chromatography (GPC)) with a two-peak distribution (with the proviso that when the copolymer is to be post -cured, the distribution is one as determined before the post cure), wherein a higher molecular weight peak is within 200,000 to 800,000, while a lower molecular weight peak is within 2,000 to 7,000;
and
(b) 20 to 250 parts by weight of one or more kinds of softeners selected from the group consisting of isopropyl myristate, isopropyl palmitate, ethyl oleate, octyldodecyl myristate, cetyl isooctanoate, octyldodecyl oleate, glyceryl tri-2-ethylhexanate, neopentyl glycol, diethyihexanoate, octyldodecyl lactate, and diisostearyl malate (with the proviso that when the content of the softener (b) exceeds 80 parts by weight, the copolymer must be post-cured);
and
(2) one or more of a drug or cosmetic active ingredient being dissolved or dispersed in said pressure-sensitive adhesive.

8 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/486,115Filed 8 Aug 2002
Priority: JP 2001-27890510 Aug 2001
Published: US 2004/0234582 A125 Nov 2004
Granted: 12 Jan 2010
Term ends: Not estimatedThe source records don’t support an estimate.

Classification25 codes

A61K 9/7061
Obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene: polyacrylates
A61L 15/42
Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons: use of materials…
A61L 15/58
Use of materials characterised by their function or physical properties: adhesives
A61L 15/585
Adhesives: mixtures of macromolecular compounds