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US 7,645,803 B2Granted
Saccharide foamable compositions
AssigneeFoamix Ltd.
InventorsDov Tamarkin, Doron Friedman, Alex Besonov
Life of this patent
Estimating the term…
Abstract
A foamable composition, containing a saccharide for use in the treatment of various disorders including: water, a saccharide, about 0.2% to about 5% by weight of a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric agent selected from a bio-adhesive agent, a gelling agent, a film forming agent and a phase change agent, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
Claims28
A foamable saccharide composition for topical administration to the skin or vaginal body cavity including:
- (i) water;
- (ii) about 50% to about 80% by weight of a saccharide selected from the group consisting of a monosaccharide, a disaccharide, an oligosaccharide, a sugar alcohol and mixtures thereof;
- or honey, in an amount that provides about 50% to about 80% by weight of a mixture of saccharides in the composition;
- (iii) about 0.2% to about 5% by weight of a surface-active agent;
- (iv) about 0.01% to about 5% by weight of at least one polymeric agent selected from a bioadhesive agent, a gelling agent, a film forming agent and phase change agent;
- and
- (v) a foam adjuvant, the foam adjuvant comprising a fatty alcohol or a fatty acid, or a mixture thereof;
- and
- a liquefied hydrocarbon propellant or compressed gas propellant at a concentration of about 3% to about 25% of the total composition;
- wherein the saccharide composition is hygroscopic;
- and wherein the composition forms a breakable foam upon dispensing.
8 more elements
A method of treatment of a disorder of a target site comprising:
- administering to a target site in need of treatment, said target site selected from the group consisting of the skin, a body surface, a body cavity or mucosal surface, the nasal cavity, the mouth, the eye, the ear canal, the vagina and the rectum;
- a saccharide composition comprising:
- (i) water;
- (ii) about 50% to about 80% by weight of a saccharide selected from the group consisting of a monosaccharide, a disaccharide, an oligosaccharide, a sugar alcohol and mixtures thereof;
- or honey, in an amount that provides about 50% to about 80% by weight of a mixture of saccharides in the composition;
- (iii) about 0.2% to about 5% by weight of a surface-active agent;
- (iv) about 0.01% to about 5% by weight of at least one polymeric agent selected from a bio-adhesive agent, a gelling agent, a film forming agent and a phase change agent;
- and
- (v) a foam adjuvant, the foam adjuvant comprising a fatty alcohol or a fatty acid, or a mixture thereof;
- and
- a liquefied hydrocarbon propellant or compressed gas propellant at a concentration of about 3% to about 25% of the total composition;
- wherein the saccharide composition is hygroscopic;
- and wherein the composition forms a breakable foam upon administration.
10 more elements
A foamable saccharide composition for topical administration comprising:
- (i) water;
- (ii) about 50% to about 80% by weight of a saccharide selected from the group consisting of a monosaccharide, a disaccharide, an oligosaccharide, a sugar alcohol and mixtures thereof;
- or honey in an amount that provides about 50% to about 80% by weight of a mixture of saccharides in the composition;
- (iii) about 0.2% to about 5% by weight of a surface-active agent;
- and
- (iv) a liquefied hydrocarbon propellant or compressed gas propellant at a concentration of about 3% to about 25% of the total composition,
- wherein the saccharide composition is hygroscopic;
- and wherein the composition forms a breakable foam upon dispensing.
5 more elements
A foamable saccharide composition for topical administration including:
- (i) water;
- (ii) about 50% to about 80% by weight of a saccharide selected from the group consisting of a monosaccharide, a disaccharide, an oligosaccharide, a sugar alcohol and mixtures thereof;
- or honey in an amount that provides about 50% to about 80% by weight of a mixture of saccharides in the composition;
- (iii) about 0.2% to about 5% by weight of a surface-active agent;
- and
- (iv) a liquefied hydrocarbon propellant or compressed gas propellant at a concentration of about 3% to about 25% of the total composition,
- wherein the foam is capable of providing an Aw value of less than about 9;
- and wherein the foam forms a breakable foam upon dispensing.
5 more elements
A method for delivering a saccharide composition, comprising
- (a) charging a container with a composition comprising a foamable carrier and a liquefied or compressed gas hydrocarbon propellant, wherein the propellant is present at a concentration of about 3% to about 25% by weight of the total composition, and wherein the carrier comprises
- (i) water;
- (ii) about 50% to about 80% by weight of a saccharide selected from the group consisting of a monosaccharide, a disaccharide, an oligosaccharide, a sugar alcohol and mixtures thereof;
- (iii) optionally honey, in an amount that provides about 50% to about 80% by weight of a mixture of saccharides in the composition;
- (iv) about 0.2% to about 5% by weight of a surface-active agent;
- (v) about 0.01% to about 5% by weight of at least one polymeric agent selected from a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent;
- and
- (vi) a foam adjuvant, the foam adjuvant comprising a fatty alcohol or a fatty acid, or a mixture thereof;
- and
- (b) dispensing the composition onto a body surface or in a body cavity, wherein the composition is dispensed as a breakable foam.
7 more elements
A foamable composition for topical administration to the skin or vaginal body cavity including:
- (i) water;
- (ii) about 50% to about 80% by weight of a sugar alcohol;
- (iii) about 0.2% to about 5% by weight of a surface-active agent;
- (iv) about 0.01% to about 5% by weight of at least one polymeric agent selected from a bioadhesive agent, a gelling agent, a film forming agent and phase change agent;
- and
- (v) a liquefied hydrocarbon propellant or compressed gas propellant at a concentration of about 3% to about 25% of the total composition, and
- wherein the saccharide composition is hygroscopic;
- and wherein the composition forms a breakable foam upon dispensing.
5 more elements
Dependencies are inferred from the claim text.