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US 7,645,789 B2Granted
Indole derivatives as CFTR modulators
AssigneeVertex Pharmaceuticals Incorporated
InventorsSara S. Hadida Ruah, Peter D. J. Grootenhuis, Fredrick Van Goor, Jinglan Zhou, Brian Bear, Mark T. Miller, Jason McCartney, Mehdi Michel Djamel Numa
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Abstract
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Claims3
A compound of formula:
- or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising
- (i) a compound of formula:
- (ii) a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.