Adjuvant viral particle
AssigneeFolia Biotech Inc.
InventorsDenis Leclerc, Nathalie Majeau, Constantino III Roberto López-Macías
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Abstract
The present invention relates to an immunogen-carrier having immunopotentiating or adjuvant properties. More particularly, the immunogen-carrier is a virus-like particle (VLP) from the family of potexvirus, and most particularly the papaya mosaic virus. The VLP produced by recombinant techniques is in fusion with one of its own proteins a protein immunogen. The above VLP and a protein or a protein extract from a viral, bacterial or parasital pathogen may be used as a vaccine.
Claims35
A method of potentiating an immune response against an antigen comprising one or more B-cell antigenic epitopes and/or one or more T-cell antigenic epitopes in an animal, said method comprising the step of administering to said animal said antigen and an effective amount of an adjuvant, wherein said adjuvant is a papaya mosaic virus (PapMV), or a virus-like particle (VLP) comprising PapMV coat protein, said PapMV coat protein being capable of assembling to form said VLP,
- wherein said antigen is fused to the C-terminus of a coat protein of said VLP, such that said antigen is disposed on the outer surface of the PapMV or VLP, and
- wherein said immune response is a humoral and/or cellular response.
A method of potentiating a humoral and/or cellular immune response against an antigen comprising one or more B-cell antigenic epitopes and/or one or more T-cell antigenic epitopes in an animal, said method comprising the step of administering to said animal said antigen and an effective amount of an adjuvant, wherein said adjuvant is a virus-like particle (VLP) comprising PapMV coat protein, said PapMV coat protein being capable of assembling to form said VLP,
- wherein said antigen is fused to the C-terminus of said PapMV coat protein.
Dependencies are inferred from the claim text.