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US 7,641,891 B2Granted
Chimeric, human and humanized anti-CSAp monoclonal antibodies
AssigneeImmunomedics, Inc.
InventorsHans J. Hansen, David M. Goldenberg
Life of this patent
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Abstract
The present invention provides humanized, chimeric and human anti-CSAp antibodies and anti-CSAp antibody fusion proteins that are useful for the treatment and diagnosis of various cancers, including colon cancer.
Claims25
An isolated anti-CSAp monoclonal antibody or an immunoreactive fragment thereof that competes for binding to CSAp with an antibody comprising the light chain complementarity determining region (CDR) sequences CDR1 (RSSQSIVHSNGNTYLE, SEQ ID NO:
- 1);
- CDR2 (KVSNRFS, SEQ ID NO:
- 2) and CDR3 (FQGSRVPYT, SEQ ID NO:
- 3);
- and the heavy chain CDR sequences CDR1 (EYVIT, SEQ ID NO:
- 4);
- CDR2 (EIYPGSGSTSYNEKFK, SEQ ID NO:
- 5) and CDR3 (EDL).
5 more elements
Dependencies are inferred from the claim text.