# US 7,639,853 B2 · Method of and system for predicting dose delivery > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 7,639,853 B2 - Document ID: US7639853B2 - Status: Granted - Kind: B2 - Application number: 11/459,066 - Filed: 2006-07-21 - Published: 2007-02-22 - Granted: 2009-12-29 - Earliest claimed: 2005-07-22 - Assignees: Tomotherapy Incorporated - Inventors: Gustavo H. Olivera; Kenneth J. Ruchala; Eric Schnarr; Jeffrey M. Kapatoes; Weiguo Lu; Jason Haimerl; John H. Hughes; Thomas R. Mackie - Web page: https://patentgrep.com/patent/US7639853B2 ## CPC - A61N 5/103: {Treatment planning systems} - A61N 5/1038: {taking into account previously administered plans applied to the same patient, i.e. adaptive radiotherapy} - A61N 5/1048: {Monitoring, verifying, controlling systems and methods} - A61N 5/1042: {with spatial modulation of the radiation beam within the treatment head} - A61N 5/1049: {for verifying the position of the patient with respect to the radiation beam} - A61N 5/1065: {Beam adjustment} - A61N 5/1069: {Target adjustment, e.g. moving the patient support} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract A system and method of predicting a radiation dose to be delivered to a patient. The method includes the acts of generating a first image of at least a portion of the patient, defining a treatment plan for the patient, generating a second image of at least a portion of the patient while the patient is substantially in a treatment position, updating the patient profile with the second image, and predicting the radiation dose to be delivered to the patient based upon the patient profile and the treatment plan. ## Claims ### Claim 1 A method of predicting a radiation dose delivered to a patient in the delivery of a treatment plan to the patient, the patient having a profile, the method comprising: generating a first image of at least a portion of the patient; defining a treatment plan for the patient; generating a second volumetric image of at least a portion of the patient while the patient is substantially in a treatment position; updating the patient profile with the second image; and calculating using a computer the radiation dose to be delivered to the patient based upon the patient profile and the treatment plan. ### Claim 2 (depends on 1) A method as set forth in claim 1 wherein the profile is determined at least in part by the actual or intended patient position. ### Claim 3 (depends on 1) A method as set forth in claim 1 wherein the patient profile includes data related to a device that delivers radiation therapy, and wherein the device data is used to predict the radiation dose to be delivered to the patient. ### Claim 4 (depends on 1) A method as set forth in claim 1 wherein the patient profile includes motion data. ### Claim 5 (depends on 1) A method as set forth in claim 1 and further comprising evaluating past data to determine a combination of known dose delivered and predicted dose to be delivered based on the patient profile. ### Claim 6 (depends on 1) A method as set forth in claim 1 and further comprising collecting data during delivery of the treatment plan and comparing the predictive dose to the actual dose delivered to the patient. ### Claim 7 (depends on 1) A method as set forth in claim 1 further comprising changing patient position at least partially in response to the predictive dose. ### Claim 8 (depends on 1) A method as set forth in claim 1 wherein the treatment plan is changed in response to the predictive dose. ### Claim 9 (depends on 7) A method as set forth in claim 7 wherein the patient position is changed during treatment. ### Claim 10 (depends on 7) A method as set forth in claim 7 wherein the patient position is changed after treatment for subsequent treatments. ### Claim 11 (depends on 7) A method as set forth in claim 7 wherein the patient position is changed based on the expected biological effect of the predictive dose delivered. ### Claim 12 (depends on 1) A method as set forth in claim 1 wherein predicting dose to be delivered includes the use of deformable registration. ### Claim 13 (depends on 12) A method as set forth in claim 12 wherein deformable registration is used to identify contours of patient structures. ### Claim 14 (depends on 12) A method as set forth in claim 12 wherein deformable registration is used to determine dose accumulation. ### Claim 15 (depends on 1) A method as set forth in claim 1 further comprising generating a real-time, running predicted dose. ### Claim 16 (depends on 15) A method as set forth in claim 15 and further comprising using feedback to adjust the treatment plan or patient position based on the real-time, running predicted dose. ### Claim 17 (depends on 1) A method as set forth in claim 1 and further comprising acquiring data relating to clinical dose delivered and patient effect, and applying a biological model that relates the predictive dose to the patient effect. ### Claim 18 A method of determining a radiation dose to be delivered to a patient, the method comprising: generating a treatment plan for the patient; acquiring a volumetric image of at least a portion of the patient while the patient is substantially in the treatment position; calculating using a computer a plurality of doses that would be delivered to the patient for each of a plurality of patient profiles, each patient profile including the acquired image; and selecting one of the patient profiles for delivery of the treatment plan. ### Claim 19 (depends on 18) A method as set forth in claim 18 wherein the patient profile includes position data. ### Claim 20 (depends on 18) A method as set forth in claim 18 wherein the patient profile includes motion data. ### Claim 21 (depends on 18) A method as set forth in claim 18 further comprising registering the patient using the acquired image and an image from the treatment plan. ### Claim 22 A method of determining a radiation dose to be delivered to a patient, the method comprising: delivering radiation to a patient according to a predetermined treatment plan; acquiring a volumetric image of at least a portion of the patient during delivery of the radiation; calculating using a computer a radiation dose while the radiation is being delivered, the radiation dose based on at least in part on the acquired image; and determining whether to modify delivery of the radiation while the radiation is being delivered. ### Claim 23 (depends on 22) A method as set forth in claim 22 and further comprising modifying the treatment plan in response to the calculated radiation dose. ### Claim 24 (depends on 22) A method as set forth in claim 22 and further comprising adjusting a position of the patient in response to the calculated radiation dose. ### Claim 25 (depends on 22) A method as set forth in claim 22 and further comprising stopping the delivery of the radiation in response to the calculated radiation dose.