US 7,638,122 B2 · Stat3 antagonists and their use as vaccines against cancer

Abstract

The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing Stat3 (signal transducer and activator of transcription3) expression and/or function in tumor cells and the administration of such cells to a subject in need of treatment and/or prevention. Other methods of the invention comprise activating T-cells by co-culturing the T-cells with the tumor cells with decreased Stat3 expression or function. The invention further encompasses methods comprising decreasing Stat3 expression or function in antigen-presenting cells and co-administering tumor cells and the antigen-presenting cells with decreased Stat3 function to a patient. The invention further relates to methods for stimulating dendritic cell differentiation.

Claims12

Dependent claims

A method for treating cancer in a subject, said method comprising:

(a) decreasing Stat3 expression or function in a tumor cell ;
(b) culturing the tumor cells obtained in step (a);
(c) contacting antigen-presenting cells with supernatant obtained from the culture of step (b), wherein the supernatant is irradiated before contacting the antigen-presenting cells with the supernatant;
(d) contacting cytotoxic T cells with the antigen-presenting cells of step (c), thereby activating the cytotoxic T cells;
and (e) administering the cytotoxic T cells to the subject, such that the cancer in the subject is treated.

2 more elements

Dependencies are inferred from the claim text.

Stat3 antagonists and their use as vaccines against cancer

Life of this patent

Stat3 antagonists and their use as vaccines against cancer

Life of this patent

Abstract

Claims12